Translational human gut microbiome research: A path from theory towards clinical and public health impact

The purpose of this PhD thesis was to explore the translational pathway of human gut microbiome research through the lens of translational medical research principles.
From placing humanity-centred values at the heart of medical research in its opening pages, to embracing a global health perspective in its closing reflections, this thesis integrates translational medical research into human gut microbiome research, encompassing microbial ecology, nutrition, antibiotic perturbation, and metabolic health.
Each chapter represents a distinct phase of the translational research continuum (T0–T4), progressing from foundational theory, basic & preclinical studies, to clinical research, and leading to the development of an actionable framework proposed to advance effective translation of human gut microbiome knowledge into clinical practice and public health.