The image shows results from an ongoing project at the chairgroup of Biochemistry, in which cell polarity of plants is studied. In order for multicellular organisms to develop correctly, it is crucial for cells ‘to know’ their orientation within the organism. The SOSEKI proteins function as a compass in the cell, by localising in specific corners. This was visualised by tagging SOSEKI proteins in vivo with YFP. Furthermore, the 3D structure was obtained by X-RAY Diffraction, which showed that the protein can polymerise. This is a good example of how an interdisciplinary approach can answer fundamental biological questions.
For this specialisation, you need to choose at least two deepening courses, however you can always choose more if you want to. All details can be found in the study handbook, but some characteristic courses of this specialisation are shortly explained below:
Biochemical and molecular (cell) biology research has resulted in new insights in the strategies cells use to regulate their processes. These molecular concepts will be discussed in this course. This includes the biochemistry of regulatory strategies of cellular processes, the biochemistry of signal-transducing pathways and the human sensory systems. With vast growing amounts of data at hand, one of the most important challenges in biology is a more synthetic approach to understand connections between a cell’s building blocks, which will be extensively discussed.
Furthermore, an introduction will be given in several innovative light microscopic techniques (FRAP, FRET) and with the help of a digital case a more mathematical background of the mechanisms that drive the cell cycle will be explained.
Thesis Research Groups
The MSc thesis forms the core of your specialisation, reflected in the value of 36 ECTS. Your thesis will be part of the research of one of the chair groups of Wageningen University. The research groups that offer thesis projects within this specialisation are listed below, and you can get more details on their respective websites.