Onderwerp scriptie
How do genetic variants affect α-synuclein associated pathology?
The nematode Caenorhabditis elegans is a valuable model organism for studying human Parkinson Disease associated molecular mechanisms. We use C. elegans carrying a human copy of the α-synuclein (SNCA gene) that show the characteristic protein accumulation. In C. elegans, we can study how individual genetic differences affect α-synuclein related pathology. We currently aim to find which genes in C. elegans are implicated in accelerated α-synuclein accumulation.
Techniques that will be used:
• Recombinant inbred lines
• gene expression analysis (qPCR)
• Light microscopy
• ELISA
_____________________________________________________________________________________________
Period(s):
Period(s) in which subject is available: All periods
_____________________________________________________________________________________________
Major(s):
This thesis topic is well suited for students of the following Bachelor programmes:
BBI - Major A Cell and Molecular Biology
BBI - Major C Human and Animal health Biology
BBT
BML
_____________________________________________________________________________________________
Application:
Deadline for application for the project: at least 4 weeks
_____________________________________________________________________________________________
Project:
Type of research project: Experimental work
_____________________________________________________________________________________________