Marine spatial management is challenged by complex situations in European countries where multiple stakeholder interests and many management options have to be balanced. EU policy initiatives such as the proposed Marine Spatial Planning Directive, are in different ways targeting area allocation in European waters. In this circumstance, EU marine management needs assessments based on a satisfactory evaluation framework design that can ensure a transparent treatment of different types of information including interests, values, and facts. The main goal of this article is to introduce an evaluation framework applicable to marine management in European countries. This socalled CoExist framework maps out different types of relevant knowledge to assess future possibilities for use or no-use of marine areas and links this with appropriate management measures. The CoExist framework is based on the principles of ensuring transparent treatment of different types of information as well as appropriate stakeholder representation which can ensure legitimacy. Empirical findings in six European case studies have been obtained while conducting the CoExist framework. Applying the basic principles of the CoExist framework when planning future management directions of the coexistence of multiple activities in the long-run will expectedly affect the ecological and social-cultural goals by counterbalancing the economic ones.