Microbial systems and synthetic biology
The microbial systems and synthetic biology group uses knowledge-based bioengineering to re-design and modify microbes for biotechnological application.
Within this theme we develop novel technologies of DNA modification and genome engineering to build synthetic systems such as cells able to produce industrially relevant compounds. Those are applied to advance the development of more efficient and safer microbial cell factories, which are essential for a safe transition to a circular bio-based economy.
Methods and approaches
We use and develop methods such as:
- CRISPR interference
- biosensors
- high-throughput genome engineering tools
- knowledge guided library design and construction
Research themes
Computational systems biology
We use mathematical models to study genomes of microbes as well as their functioning.
Systems health
In this theme, we aim to predict disease onset, progression, and remission by analysing patient data.
Semantic systems biology
We link biological data in such a way computers can better understand, combine, and use them in life sciences.
Microbial systems and synthetic biology
We develop novel technologies of DNA modification and genome engineering to re-design microbes for biotechnological application.
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