Project FIBERME: an innovative AI-driven consortium predicting gut microbiome reactions to dietary fiber

The FIBERME project addresses a key challenge for the food sector: gaining clearer insight into how structurally different dietary fibers influence the human gut microbiome. Low fiber intake is widespread and associated with reduced microbial diversity and increased health risks. Because the gut microbiome plays a vital role in digestion, immune function, and overall well-being, understanding fiber–microbiome interactions is crucial for improving public health and guiding future product development.

FIBERME is an innovative initiative designed to transform our understanding of dietary fibers and their role in human health. The project focuses on predicting microbiome responses of structurally different fibers using Artificial Intelligence (AI). By improving scientific insight into these interactions, FIBERME supports the development of fiber-rich foods tailored for optimal health benefits of individuals based on their microbiome, moving the industry beyond general fiber enrichment toward more targeted applications.

Understanding Plant-Based Fibers Through Large-Scale Analysis

Plant-based fibers vary widely in their composition and structure, and these differences strongly influence microbiome responses. FIBERME examines fibers from different sources to determine which fiber fractions or combinations most effectively support (gut) health through microbiota modulation. The project specifically looks at fibers that can enhance microbial diversity and stimulate beneficial bacteria in the digestive system.

To support this work, FIBERME is creating a comprehensive database of more than 2,000 lab-based fermentation experiments. These studies show how different fibers affect gut microbiota composition and functionality. They also reveal the biochemical reactions through which gut bacteria metabolize fibers, providing insight into links with fermentation, disease prevention, and overall gut health. This dataset forms a critical foundation for understanding how specific fibers or fiber blends influence the microbiome.

A key innovation within FIBERME is its AI-driven prediction model. Combining data from human studies and fermentation analyses, the model forecasts how different dietary fibers affect the gut microbiome. This enables the food industry to design personalized, fiber-rich products that promote specific health outcomes. The project also identifies fiber blends that may enhance short-chain fatty acid production, reduce inflammation, or strengthen gut barrier integrity, supporting the development of next-generation fiber formulations.

FIBERME provides the food industry with actionable insights for creating healthier, fiber-enriched products. By optimizing fiber types and amounts, manufacturers can design foods that contribute to digestive and metabolic health and align with broader societal health goals. A planned human study will help validate laboratory findings and further refine the AI model, reinforcing its relevance for everyday health applications.

The project enhances understanding of fiber effects on the gut microbiome and supports the development of healthier, science-based food products. It also contributes to the United Nations Sustainable Development Goals, including Zero Hunger (SDG 2) by improving the use of whole crops for food production and Good Health and Well-being (SDG 3) by supporting positive microbiome impacts.

FIBERME brings together partners including Unilever, Cargill, DSM-Firmenich, Junlebao, Dossche Mills, Ingredion, Mars, Sigma Alimentos and Wageningen University & Research. This collaboration combines expertise in food science, microbiology, artificial intelligence, and human nutrition and health science. Together, the partners create a strong foundation for innovations that support both the food industry and public health.