Thesis subject

Dynamic metabolic flux measurements

Metabolic fluxes are important indicators for the cell processes. At this moment the metabolic flux measurements are based on the steady state assumptions. However, it is also very interesting to qualify the cell behaviour in its transient state. Here extra metabolites can be formed and extra products can be made. By considering the dynamics of the system the metabolic flux can be measured also during the transient. However, this method is sensitive for the quality of data and needs therefore extra attention.

The work is done in cooperation with the Process Engineering Group.