Project
Evaluation of genetic diversity
Determination and evaluation of genetic diversity within livestock breeds is of crucial importance for making the right conservation decisions and for an efficient use of resources available for conservation.
This project has the general objective of exploring the opportunities of large amounts of marker data for conservation of genetic diversity within livestock breeds. The recent availability of dense marker maps (SNP markers) for livestock species enables the evaluation of diversity for specific regions of the genome, and genetic diversity for specific traits at different regions at the genome can be localized.
The aims in this study are:
- develop scientific methods to evaluate genetic diversity across the whole genome using dense marker maps
- apply these methods to case studies, with focus on the neutral diversity over the genome and the diversity of specific traits, and the effect of selection
- translate the results into tools for the genetic conservation of livestock in gene banks
Publicaties
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Selection of SNP from 50K and 777K arrays to predict breed of origin in cattle
Journal of Animal Science (2013), Volume: 91, Issue: 11 - ISSN 0021-8812 - p. 5128-5134. -
Differences in milk fat composition predicted by mid-infrared spectrometry among dairy cattle breeds in the Netherlands
Journal of Dairy Science (2013), Volume: 96, Issue: 4 - ISSN 0022-0302 - p. 2570-2582. -
The use of whole genome sequence data to estimate genetic relationships including rare alleles information
In: Proceedings, 10th World Congress of Genetics Applied to Livestock Production - p. 47-47. -
Heritability of milk fat composition is considerably lower for Meuse-Rhine-Yssel compared to Holstein Friesian cattle
Livestock Science (2015), Volume: 180 - ISSN 1871-1413 - p. 58-64. -
Supporting genetic management of live populations with gene bank material in a cattle populations
In: Book of Abstracts of the 66th Annual Meeting of the EAAP - Wageningen: Wageningen Academic Publishers - ISBN: 9789086862696 - p. 100-100. -
Overlap in genomic variation associated with milk fat composition in Holstein Friesian and Dutch native dual-purpose breeds
Journal of Dairy Science (2015), Volume: 98, Issue: 9 - ISSN 0022-0302 - p. 6510-6521. -
Whole-genome sequence data uncover loss of genetic diversity due to selection
Genetics, Selection, Evolution (2016), Volume: 48, Issue: 1 - ISSN 0999-193X -
Which individuals to phenotape? Optimal design of reference population for genomic selection while maintaining genetic diversity
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Conservation priorities for the different lines of Dutch Red and White Friesian cattle change when relationships with other breeds are taken into account
Journal of Animal Breeding and Genetics (2017), Volume: 134, Issue: 1 - ISSN 0931-2668 - p. 69-77. -
Utility of whole genome sequence data for across breed genomic prediction