Publicaties

Cas12a nickases

van der Oost, John; Villegas Warren, Ricardo; Luteijn, Maartje Janneke; Staals, Raymond Hubert Josèphe; Wu, Wen Ying; De Vleesschauwer, David; D'Halluin, Katelijn; Meulewaeter, Frank

Samenvatting

The present invention relates to the field of gene genome editing. In particular, it relates to the provision of a Cas12a enzyme having nickase activity, as well as the means and methods for the modification of a genomic locus of interest with a Cas12a enzyme having nickase activity and uses thereof