Human and Animal Physiology
Human and Animal Physiology performs molecular physiological research and academic training focused on mechanistic understanding of energy metabolism in health and disease of humans and animals and how this can be targeted by specific nutrients to improve health.
Chair holder
Research
Research of Human and Animal Physiology (HAP) is focused on energy metabolism. A compromised energy metabolism is a central component of diet- and age-related diseases and affects organ and tissue function. By studying energy metabolism, we want to improve metabolic health and prevent disease and dysfunction. We do this by physiological and molecular physiological research that aims at understanding the role of mitochondria and intermediary metabolism in metabolic health of vertebrates and how this can be improved by nutrients, compounds and physical activity. We perform experimental research in humans, animals (with emphasis on rodents and pigs), tissues and cells, using state-of-the-art physiological, molecular, biochemical and histological tools. Results of our research are i) new mechanistic insights in metabolism related to health and organ functioning and, ii) methodology and data to substantiate the efficacy of interventions, compounds and foods to improve metabolic health.
Publications
Researchers at Human and Animal Physiology publish regularly in international, peer reviewed scientific journals.
Our latest publications
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Energy metabolism and diet
Nutrients 13 (2021)6. - ISSN 2072-6643 -
Small change, big impact: functional characterization of human SIRT5 variants
Wageningen University. Promotor(en): J. Keijer, co-promotor(en): V.C.J. de Boer. - Wageningen : Wageningen University - ISBN 9789463957212 - p. -
Substrate-Driven Differences in Tryptophan Catabolism by Gut Microbiota and Aryl Hydrocarbon Receptor Activation
Molecular Nutrition & Food Research (2021). - ISSN 1613-4125