Micro- and nano-NMR
We develop miniature NMR technologies that make it possible to study extremely small sample volumes with high sensitivity. By shrinking NMR coils and integrating them into microchips, we can create compact, versatile, and relatively low-cost devices.
One major application is the study of catalytic reactions inside microreactors. Instead of only analysing the final product at the reactor outlet, we aim to measure directly inside the tiny reaction channel itself. We are building a micro-NMR probe that can detect microlitre volumes within a microreactor coated with catalytic nanoparticles. As a model system, we investigate mild hydrogenation reactions. This combined micro-NMR and microreactor setup is new and may contribute to the more rational design of improved catalysts.
Enhancing NMR signals
We also participate in a European project to enhance NMR signals using hyperpolarisation techniques. These methods dramatically increase signal intensity by transferring polarisation from other sources to the nuclei being measured. Within our group, we combine hyperpolarisation with the design of ultra-small NMR coils to reach sensitivity levels down to the femtomole range. This allows us to detect analytes present in extremely low amounts or concentrations, and to perform measurements much more quickly.