Supramolecular interactions in solution and on surfaces
We study how molecules interact in solutions and on surfaces using supramolecular chemistry, which focuses on non-covalent interactions. These include forces such as hydrogen bonding, van der Waals interactions, electrostatic attraction, metal–ligand coordination, and host–guest binding. Because these interactions are reversible and highly specific, they are powerful tools for building complex molecular structures.
A key part of our work involves host–guest chemistry using cyclodextrins: ring-shaped molecules that can bind small hydrophobic compounds. This binding behaviour is useful for sensing. For example, the interaction between cyclodextrin and phenolphthalein can be used to detect ibuprofen. By attaching cyclodextrins to nanoparticles, we create sensitive readout systems for detecting enzymes or proteins such as lectins in solution.
Microcontact printing
We also use microcontact printing (µCP), a soft lithography technique that allows us to print precise molecular patterns onto surfaces like glass, silicon, or gold. A patterned PDMS stamp is coated with the desired (bio)molecules and pressed onto the substrate, transferring the pattern. µCP offers excellent spatial control, even at the nanoscale, and enables applications ranging from FRET-based sensors to structured surfaces for flow-cell experiments. Current research focuses both on producing new functionalised surfaces and on applying them in biomedical and catalytic contexts.