Project

Nanoscale Microscopy and Spectroscopy of Biomolecular Systems

My research focuses on exploring the intricate world of protein and protein aggregation, a phenomenon of great significance in various diseases, including neurodegenerative disorders, as well as its applications in material science. Within the framework of Nanoscale Microscopy and Spectroscopy research group, my primary objective is to comprehensively characterize the heterogeneity within protein aggregates, aiming to gain insights into their structural, chemical, and nanomechanical complexities.
I employ cutting-edge state-of-the-art techniques, including Atomic Force Microscopy-based Infrared Nano Spectroscopy (AFM-IR), Peak Force Quantitative Nanomechanical Mapping (PF-QNM), and bulk spectroscopic methods, to investigate the structural, chemical, and nanomechanical characteristics of proteins and protein aggregates. These findings hold significant implications for both the fields of biology and material science. Some of the specific areas of study within my research include Tau phosphorylation, liquid-liquid phase separation, and brain biopsies.