BIO-SPEC for data-driven bioprocess scale-up

The benefits

In short

Real-time insight into critical process parameters
Faster and more reliable scale-up
Lower development costs and fewer failed scale-up trajectories
Access to high-quality infrastructure for startups, SMEs, and industry
Integration of AI, digital twins, and FAIR data management for advanced process optimisation

BIO-SPEC assists companies and researchers scale up chemical, enzymatic, and microbial processes faster, more reliably, and more cost-effectively through real-time process monitoring, AI, and digital twins.

About BIO-SPEC

Many innovative fermentation, enzymatic, and chemical processes fail during scale-up because process performance is insufficiently monitored and understood. BIO-SPEC (Bioprocess Innovation & Optimisation through Sensing, PAT, Engineering and Control) assists companies, knowledge institutions, and public organizations bridge this so-called "scale-up gap".

BIO-SPEC combines advanced Process Analytical Technologies (PAT), including Raman and NIR spectroscopy, with AI-driven data analysis, digital twins, and a mobile measurement unit for on-site applications. This enables processes to be monitored, optimised, and reproducibly scaled up from laboratory scale to industrial production in real time.

BIO-SPEC supports innovation in food production, fermentation, alternative proteins, biobased chemicals, side-stream valorisation, and sustainable materials. This research infrastructure is available for public-private partnerships, contract research, and shared-use of the Process Analytical Tools for companies and research organisations.