At the Laboratory of Biochemistry the emphasis is on proteins. The central theme is Cellular Biochemistry in which we link protein structure and function to protein activity in a cell and finally to protein function in a complete organism.
Proteins of interest are identified based on the ability of their encoding genes to, for instance, change the fate of a cell, have a function in a precise cellular context or carry out an interesting enzymatic reaction. Transcriptional regulators control networks of genes and are studied at the protein structure level, their dynamics inside cells and their function in cellular and organismal context. Proteomics, as an essential element of systems biology, allows all proteins and their post-translational modifications as present in a cell to be studied simultaneously. Enzyme kinetics, 3D protein structure, protein interaction with other proteins and with ligands or substrates are commonly addressed using purified proteins.
To apply the power of modern sophisticated biochemical techniques to study proteins at the Laboratory of Biochemistry it is essential, in the ideal situation, that all state-of-the-art facilities, including FT-MS, are available. We are, together with the laboratories of Biophysics, Organic Chemistry and Molecular Biology, host of the WUR Technology Platforms MicroSpectroscopy Centre (MSC) and Wageningen NMR Centre (WNMRC), and collaborate extensively with IRB and IBMB-CSIC, Barcelona for crystallographic protein structure determinations.
If you follow the link “Research” you will find short descriptions of the individual projects within these main areas and the people that are doing the work. There is continuous cross-talk between the projects within and between the main areas. Following the link from “Education” via MSc thesis projects, you will find a summary of those projects that are currently available for students.