The role of the gut microbiota in the toxicity of foodborne chemicals
The gut microbiota has an important effect on human health through a wide range of biochemical and metabolic activities that influence the host’s exposure to toxic xenobiotic compounds and their metabolites. Examples of compounds that are affected by gut microbial metabolism are drugs, such as sorivudine and sulfasalazine, but also foodborne adulterants like melamine, and natural chemicals like glucosinolates, lignans, and isoflavones. The gut microbial metabolism of foodborne xenobiotics and the biological activities of metabolites formed are studied, and these data are integrated into physiologically based kinetic models and risk-benefit analyses.
The research topics under this theme are as follows
The role of the microbiome on plasma metabolite patterns of selected model compounds
- PhD: Christina Behr; promotion in 2019
- Supervisors: Ivonne Rietjens, Ben van Ravenzwaay
Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
- PhD: Qianrui Wang; promotion in 2021
- Supervisors: Ivonne Rietjens, Karsten Beekmann
The role of the gut microbiota in the toxicity and risk assessment of foodborne chemicals
- PhD: Jing Jin; promotion in 2021
- Supervisors: Ivonne Rietjens, Karsten Beekmann
The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone
- PhD: Diana Marisol Mendez Catala; promotion in 2021
- Supervisors: Ivonne Rietjens, Karsten Beekmann
Unravelling the functional dynamics between the human gut microbiome and intestinal inflammatory responses.
- PhD: Menno Grouls; promotion in 2021
- Supervisors: Ivonne Rietjens, Hans Bouwmeester
