This group focuses on investigating and exploiting genetic variation and biodiversity. It develops and employs various genetic and genomic technologies (including motif directed profiling) to assess biodiversity between and within species, focusing on genetic variation at the allelic level.
Developing technologies for high throughput analysis is another point of attention. Structure and inheritance of the genetic variation is studied using genetic marker maps and through haplotype reconstruction. The study of neutral genetic variation is used in phylogenetic studies and for quantification of dispersal and gene flow.
Key focus area's
The study of functional diversity includes allelic variation for various quality and resistance traits and for the occurrence of allergens (PR10 proteins in apple and birch, gluten protein families in wheat).
Breeding for varieties with reduced allergenicity
In the Western society, prevalence and severity of allergies are rapidly increasing. Our research focus is on solutions for allergy-related matters in the pre-medical stage. We study the diversity of allergens in germplasm, and develop strategies to lower the amount of allergens by breeding. In this way we aim to prevent rather than cure.
The effect of polarity on the molecular exchange dynamics in imine-based covalent adaptable networksPolymer Chemistry 12 (2021)11. - ISSN 1759-9954 - p. 1635 - 1642.
Development of a new tool (4TREE) for adapted genome selection in European tree species
The origin and widespread occurrence of Sli based self-compatibility in potato: Wageningen University
Using molecular markers in breeding: ornamentals catch upActa Horticulturae 1283 (2020). - ISSN 0567-7572 - p. 49 - 53.
Detection of novel QTLs for late blight resistance derived from the wild potato species Solanum microdontum and Solanum pampasenseGenes 11 (2020)7. - ISSN 2073-4425 - 18 p.
The origin and widespread occurrence of Sli-based self-compatibility in potatoTheoretical and Applied Genetics 133 (2020). - ISSN 0040-5752 - p. 2713 - 2728.
CRISPR/Cas9 Gene Editing of Gluten in Wheat to Reduce Gluten Content and Exposure—Reviewing Methods to Screen for Coeliac SafetyFrontiers in Nutrition 7 (2020). - ISSN 2296-861X
Polynucleotide constructs and methods of gene editing using CPF1Octrooinummer: WO2019238772, gepubliceerd: 2019-12-19.
Green Plant Biotechnology at workWageningen : Groen Kennisnet
CRISPR/cas9 bij embryo's & planten
- Johan Willemsen
- Manos Domazakis
- Aurelie Jouanin
- Aviv Andriani
- Carolina Aguilera Galvez
- Xiao Lin
- Yerisf Torres Ascurra
- Xinfang Wang
- Thijs van Dijk
- Daniel Danial
- Angela Machacilla
- Bjarne Larsen
- Giorgio Tumino
- Reinhafd Simon